Two new compounds from an endophytic fungus Aspergillus sp. HS-05

Lin Zhang School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China

Gang Chen School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China

Hong-Hua Wu School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China

Xuan Lu School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China

Yue-Hu Pei School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China

Xin Wu School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, 110016, China

Bo Pan School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China

Hui-Ming Hua School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China

Jiao Bai School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, ChinaCorrespondence[email protected]

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Abstract

Two new compounds, N-[4′-hydroxy-(E)-cinnamoyl]-l-tyrosine methyl ester (1) and methyl 4-methoxy-3-(3′-hydroxy-2′-methyl)propionyloxy-benzoate (2), were isolated from EtOAc extract of the fermentation broth of the endophytic fungus Aspergillus sp. HS-05. Their structures were elucidated by NMR, IR, UV, MS, and CD methods. Compounds 1 and 2 showed no anticancer activities against HL-60 cell lines (both of IC₅₀>100 μM) in vitro.

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Acknowledgements

This work was supported by the Ministry of Science and Technology of China ‘Hi-Tech Research and Development Program of China’ (863 project), under Contract No. 2007AA09Z435, and ‘the National Natural Science Foundation of China’ under Contract No. 40776098.

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Two new compounds from an endophytic fungus Aspergillus sp. HS-05

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Two new compounds from an endophytic fungus Aspergillus sp. HS-05

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