Pestalotiopamide E, a new amide from the endophytic fungus Pestalotiopsis sp.

Jing Xu Hainan Key Laboratory of Tropical Bioresource Sustainable Utilization, Provincial Department of National Key Laboratory Breeding Base, College of Material and Chemical Engineering, Hainan University, Haikou, 570228, China; Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität, Geb. 26.23, Universitätsstrasse 1, D-40225, Düsseldorf, Germany

Qiang Lin Hainan Key Laboratory of Tropical Bioresource Sustainable Utilization, Provincial Department of National Key Laboratory Breeding Base, College of Material and Chemical Engineering, Hainan University, Haikou, 570228, China

Bin Wang School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan, 316000, China

Victor Wray Department of Structural Biology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, D-38124, Braunschweig, Germany

Wen-Han Lin National Research Laboratories of Natural and Biomimetic Drugs, Peking University, Health Science Center, Beijing, 100083, China

Peter Proksch Hainan Key Laboratory of Tropical Bioresource Sustainable Utilization, Provincial Department of National Key Laboratory Breeding Base, College of Material and Chemical Engineering, Hainan University, Haikou, 570228, ChinaCorrespondence[email protected]

Abstract

Chemical examination of the endophytic fungus Pestalotiopsis sp., isolated from the leaves of the Chinese mangrove Rhizophora mucronata, yielded a new amide called pestalotiopamide E (1). The structure of the new compound was unambiguously elucidated on the basis of extensive spectroscopic data analysis.

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Acknowledgements

The financial support by the grants of the Bundesministerium für Bildung und Forschung (BMBF) and the Ministry of Science and Technology (MOST) (2006AA09Z446) to Peter Proksch and Wen-Han Lin is gratefully acknowledged. Jing Xu is grateful to the Youth Foundation (qnjj1005), Dr Research Starting Found (kyqd1066) of Hainan University, and the Zhejiang Provincial Natural Science Foundation of China (Y2080579) for partial support.

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Pestalotiopamide E, a new amide from the endophytic fungus Pestalotiopsis sp.

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Pestalotiopamide E, a new amide from the endophytic fungus Pestalotiopsis sp.

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