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Abstract
Two new neolignans, schilancifolignans D and E (1 and 2), together with eight known ones, were isolated from the leaves and stems of Schisandra lancifolia. The structures of 1 and 2 were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were tested for their anti-HIV-1 activities and cytotoxicity. Both showed significant potential cytotoxic ability and weak anti-HIV-1 activities.
Acknowledgements
This project was supported financially by the National Nature Science Foundation of China (Nos 30830115 and 20802082), projects from the Chinese Academy of Sciences (Nos KSCX2-EW-Q-10 and KSCX1-YW-R-24), 973 Program (Nos 2009CB522303, 2009CB522306, and 2009CB940900), the Scientific and Technological projects of China (No. 2009ZX09501-029), the Yong Academic and Technical Leader Rising Foundation of Yunnan Province (No. 2006PY01-47), and the Natural Science Foundation of Yunnan Province (Nos 2005XY04 and 2006B0042Q).