Cichorin A: a new benzo-isochromene from Cichorium intybus

Hidayat Hussain Department of Chemistry, Universität Paderborn, Warburger Straße 100, 33098, Paderborn, GermanyCorrespondence[email protected]

Javid Hussain Department of Chemistry, Kohat University of Science and Technology, Kohat, Khyber Pakhtunkhwa, Pakistan

Muhammad Saleem Department of Chemistry, The Islamia University of Bahawalpur, Baghdad Campus-ul-Jadid, Bahawalpur, 63000, Pakistan

Ghulam Abbas Miana Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan

Muhammad Riaz NUST Center of Virology and Immunology, National University of Science and Technology, H-12, Islamabad, Pakistan

Karsten Krohn Department of Chemistry, Universität Paderborn, Warburger Straße 100, 33098, Paderborn, Germany

Saeed Anwar Department of Chemistry, Islamia College Peshawar, University of Peshawar, Peshawar, N.W.F.P, Pakistan

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Abstract

One new benzo-isochromene, named cichorin A (1), together with three known compounds oleanolic acid, β-sitosterol, and β-sitosterol glucopyranoside, was isolated from Cichorium intybus. The structure of the new compound was elucidated by detailed spectroscopic analysis such as ¹H, ¹³C NMR, COSY, HMQC, HMBC, and HR-EI-MS. Relative configuration of asymmetric centers of cichorin A (1) was determined by the analysis of the ¹H NMR coupling constants together with the NOESY experiment.

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Cichorin A: a new benzo-isochromene from Cichorium intybus

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Cichorin A: a new benzo-isochromene from Cichorium intybus

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