Conversional synthesis and cytotoxic evaluation of novel taxoid analogs

Lei Song Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu, 610041, China

Qiao-Hong Chen Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu, 610041, China

Xue-Ke She Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu, 610041, China

Xiao-Guang Chen Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, 100050, China

Feng-Peng Wang Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu, 610041, ChinaCorrespondence[email protected]

Abstract

Four novel taxoid analogs were conversionally synthesized from the C₁₉-diterpenoid alkaloid deltaline, and their cytotoxic activities were evaluated against a small panel of cancer cell lines.

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Acknowledgement

We are grateful to the National Natural Science Foundation of China (No. 30873147) for financial support of this research.

Notes

^†Present address: Key Laboratory of Modern Chinese Medicines (China Pharmaceutical University), Ministry of Education, Tongjia lane, Nanjing 210009, China.

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Conversional synthesis and cytotoxic evaluation of novel taxoid analogs

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Conversional synthesis and cytotoxic evaluation of novel taxoid analogs

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