A new furanoxanthone from the stem bark of Calophyllum inophyllum

Abstract

The stem bark extracts of Calophyllum inophyllum furnished one new furanoxanthone, inophinnin (1), in addition to inophyllin A (2), macluraxanthone (3), pyranojacareubin (4), 4-hydroxyxanthone, friedelin, stigmasterol, and betulinic acid. The structures of these compounds were determined by spectroscopic analysis of 1D and 2D NMR spectral data (¹H, ¹³C, DEPT, COSY, HMQC, and HMBC) while EI-MS gave the molecular mass. The new xanthone, inophinnin (1), exhibited some anti-inflammatory activity in nitric oxide assay.

Keywords:

• inophinnin
• furanoxanthone
• Calophyllum inophyllum
• Guttiferae

Acknowledgements

The authors acknowledge financial support from UPM and MOSTI under the Agri Science Fund. Special thanks go to Assoc. Prof. Dr Jegak Uli for collection of plant samples and Mr Yong Yoke Keong for anti-inflammatory assay screening.