A new chromone from Angelicapolymorpha with cytotoxic activity

Abstract

A new chromone polymorchromone B was isolated and characterized from the roots of Angelica polymorpha Maxim, a commonly used traditional Chinese medicine. On the basis of spectroscopic analysis, including IR, HR-ESI-MS, 1D and 2D NMR spectral data, and hydrolysis followed by chromatographic analysis, the structure of the new chromone was elucidated as 5-hydroxy-2-[(angeloyloxy)methyl]-2′-(dimethyl)-3′-(2S,3S-epoxy-2-methylbutanoate)-dihydropyran [3′,2′:6,7]chromone. Moreover, it was found that polymorchromone B showed remarkable cytotoxic activity against A-549 cell lines.

Keywords:

• Angelica polymorpha
• chemical constituents
• polymorchromone B
• cytotoxic activity

Acknowledgments

The authors wish to express their gratitude to Prof. Jian Ren and Prof. Bin Ma, Shandong University, for providing facilities for measurements of NMR spectra. Thanks are due to Prof. Yong-jun Liu and Prof. Ke-liang Xue, Institute of Materia Medica, Shandong Academy of Medical Sciences, for providing facilities for measurements of ESI-MS and IR.