Two new N-acetyldopamine tetrapolymers from Periostracum Cicadae

Abstract

Two new N-acetyldopamine tetrapolymers, cicadamide A (1) and cicadamide B (2), were isolated from Periostracum Cicadae, and their structures were elucidated as 3-acetylamino-7-(3″-acetylamino-7″-(N-acetyl-2‴-aminoethyl)-1″,4″-benzodioxan-2″-yl)-2-(2′-(3″″,4″″-dihydroxyphenyl)-3′-acetylamino-1′,4′-benzodioxan-7′-yl)-1,4-benzodioxane (1) and 3-acetylamino-7-(3″-acetylamino-6″-(N-acetyl-2‴-aminoethyl)-1″,4″-benzodioxan-2″-yl)-2-(2′-(3″″,4″″-dihydroxyphenyl)-3′-acetylamino-1′,4′-benzodioxan-7′-yl)-1,4-benzodioxane (2), by the combined analysis of 1D NMR and 2D NMR, and mass spectrometry. Pharmacological investigation on two compounds obtained in this study showed that part of them had anti-inflammatory activities.

Keywords:

• Cryptotympana pustulata
• N-acetyldopamine tetrapolymers
• anti-inflammatory activities

Acknowledgments

This work was financially supported by the National Key Technologies R&D program of China during the 11th Five-Year Plan Period (2006BAI09B06-01) and the National Major Special Science and Technology Project (2010ZX09401-304-104A). We are grateful to Prof. Jin-Cai Lu for identification of the material.