Three new monomeric indole alkaloids from the roots of Catharanthus roseus

Chun-Hua Wang Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, China; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, China

Guo-Cai Wang Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, China

Ying Wang Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, China

Xiao-Qi Zhang Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, China

Xiao-Jun Huang Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, China

Wen-Cai Ye Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, China; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, ChinaCorrespondence[email protected]

Abstract

Two new alkaloid glycosides (1 and 2) and a new monomeric indole alkaloid (3), together with 13 known ones (4–16), were isolated from the roots of Catharanthus roseus. The structures of new compounds were elucidated on the basis of the spectroscopic methods. The absolute configuration of compound 3 was established by the modified Mosher's method.

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Acknowledgements

This work was supported by grants from Changjiang Scholars and Innovative Research Team in the University (IRT0965) and National Natural Science Foundation of China (U 0932004; Nos 81001374, 30901848, 90913020).

Notes

^† The authors contributed equally to this work.

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Three new monomeric indole alkaloids from the roots of Catharanthus roseus

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Three new monomeric indole alkaloids from the roots of Catharanthus roseus

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