A new biflavonoid with antiviral activity from the roots of Wikstroemia indica

Wei-Huan Huang Biology Program, School of Life Science, The Chinese University of Hong Kong, New Territories, Hong Kong, SAR, China

Guang-Xiong Zhou Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou, 510632, China

Guo-Cai Wang Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou, 510632, China

Hau-Yin Chung Biology Program, School of Life Science, The Chinese University of Hong Kong, New Territories, Hong Kong, SAR, China

Wen-Cai Ye Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou, 510632, China

Yao-Lan Li Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou, 510632, ChinaCorrespondence[email protected]

Abstract

A new biflavonoid, 4′-methoxydaphnodorin E, was isolated from the antiviral fraction of Wikstroemia indica against respiratory syncytial virus (RSV). Its structure was determined on the basis of extensive spectroscopic data including HR-ESI-MS and 2D NMR. The biflavonoid was tested for its in vitro anti-RSV activity with cytopathic effect (CPE) reduction assay, and displayed potent effect with 50% inhibitory concentration (IC₅₀) value of 2.8 μM and selective index (SI) value of 5.4.

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Acknowledgements

This research program was supported financially by the Natural Science Foundation of China (81072535), and the Team Project of Natural Science Foundation of Guangdong Province (8351063201000003).

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A new biflavonoid with antiviral activity from the roots of Wikstroemia indica

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A new biflavonoid with antiviral activity from the roots of Wikstroemia indica

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