Phenolic compounds from Nicotiana tabacum and their biological activities

Abstract

Three new phenolic compounds, nicotphenols A–C (1–3), together with 14 known phenols (4–17), were isolated from the leaves of Nicotiana tabacum. Their structures were established by means of spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1–3 were tested for their anti-HIV-1 activities and cytotoxicities. They all showed significant cytotoxic abilities and modest anti-HIV-1 activities, respectively.

Keywords:

• Nicotiana tabacum
• phenolic compounds
• nicotphenols A–C
• anti-HIV-1 activities
• cytotoxicities

Acknowledgements

This project was supported financially by the Excellent Scientific and Technological Team of Yunnan (2009CI014) and the Natural Science Foundation of Yunnan Province (2008B0042Q).