Two new sesquiterpene lactones from the supercritical fluid extract of Centipeda minima

Peng Wu Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, China

Xiao-Guang Li The Joint Laboratory for Brain Function and Health, Jinan University, Guangzhou, 510632, China

Ning Liang Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, China

Guo-Cai Wang Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, China

Wen-Cai Ye Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, China

Guang-Xiong Zhou Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, ChinaCorrespondence[email protected]

Yao-Lan Li Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, ChinaCorrespondence[email protected]

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Abstract

Two new sesquiterpene lactones, minimolides G (1) and H (2), were isolated from the supercritical fluid extract of Centipeda minima. Their structures were elucidated on the basis of extensive analyses of spectroscopic data including IR, HR-ESI-MS, 1D and 2D NMR. Compounds 1 and 2 displayed inhibitory activity against human nasopharyngeal cancer cell line (CNE) with IC₅₀ values of 61.4 and 28.7 μM, respectively.

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Acknowledgments

This work was supported financially by the National Natural Science Foundation of China (No. 30840099) and the Natural Science Foundation of Guangdong, China (No. 9151064101000027).

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Two new sesquiterpene lactones from the supercritical fluid extract of Centipeda minima

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Two new sesquiterpene lactones from the supercritical fluid extract of Centipeda minima

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