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Abstract
Two new C13-norisoprenoids, named lyratols E and F (1–2), were isolated from the whole plant of Solanum lyratum Thunb, and their structures were elucidated by extensive spectroscopic analyses. In vitro, two new compounds were found to show significant cytotoxicity against selected cancer cells including P-388 and HT-29.
Acknowledgments
This study was financially supported by the Natural Science Foundation of Shandong Province (No. ZR2009CZ004). The authors are grateful to Ms Hong Yu and Li Shen (School of Pharmaceutical Science, Yantai University) for the measurement of FAB-MS, HR-FAB-MS, UV, IR, and NMR spectra, respectively. The authors also gratefully acknowledge Mr Liang Ye (School of Pharmaceutical Science, Yantai University) for the bioactivity screenings.