A new auronol from Cudrania cochinchinensis

Abstract

A new auronol, cudrauronol (1), was isolated from the roots of Cudrania cochinchinensis along with 10 known compounds, 1,3,5-trihydroxy-4-prenylxanthone (2), 1,3,7-trihydroxy-4-prenylxanthone (3), 3,4′,5,7-tetrahydroxydihydroflavonol (4), kaempferol (5), 3,6-dihydroxy-1,5-dimethoxyxanthone (6), 2′,4′,5,7-tetrahydroxyflavanolol (7), 3,7-dihydroxy-1-methoxyxanthone (8), 1,3,5-trihydroxyxanthone (9), cudraflavone B (10), and 2′-oxyresveratrol (11). Compounds 1–8 were evaluated for anti-inflammatory activity on lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages. Compounds 2–5 were more active than aminoguanidine, with IC₅₀ values of 8.8, 23.2, 27.1, and 11.9 μM, respectively.

Keywords:

• Cudrania cochinchinensis
• auronol
• cudrauronol
• anti-inflammatory

Acknowledgments

We are grateful to the National Center for High-performance Computing, Taipei, Taiwan, for computer time and facilities. This research was supported by the National Science Council of Taiwan (NSC 98-2320-B-241-003-MY3).