Secondary metabolites from fungus Nigrospora sp.

Abstract

Six compounds were purified from the extracts of fungus Z18-17 (Nigrospora sp.) isolated from Scyphiphora hydrophyllacea, a tree from the intertidal zone of Shankou, Guangxi Province of China, which was reported to have cytotoxic activity. Systematic study on the chemical constituents of Nigrospora sp. resulted in the isolation of one new 6-phenylhexanoic acid derivative, one new derivative of uridine, and four known compounds. Their structures were characterized, respectively, as methyl 5-acetamido-6-(4-hydroxyphenyl)-4-oxohexanoate (1), uridine-5′α-hydroxypropanoate (2), 4-hydroxyphenethyl 2-hydroxypropanoate (3), methyl pyroglutamate (4), cyclo (Pro-Val) (5), and cyclo (Phe-Hyp) (6). The cytotoxic activities of the two new compounds against HL-60 cell line were tested and the IC₅₀ values of the two new compounds were all over 100 μM.

Keywords:

• Scyphiphora hydrophyllacea
• Nigrospora sp.
• second metabolites

Acknowledgements

This study was financially supported by the Ministry of Science and Technology ‘863’ project of China under Contract Nos 2007AA09Z413 and 2007AA09Z435 and the National Natural Science Foundation of China under Contract No. 40776098.