Two new diterpenes, neocaesalpin MR and minaxin C, from Caesalpinia minax

Guo-Xu Ma Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100193, China

Na Xu Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100193, China

Jing-Quan Yuan National Engineering Laboratory of Southwest Endangered Medicinal Resources Development, National Development and Reform Commission, Guangxi Botanical Garden of Medicinal Plant, Nanning, 530023, China

Hua Wei Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China

Qing-Xia Zheng Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100193, China

Zhao-Cui Sun Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100193, China

Jun-Shan Yang Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100193, China

Xu-Dong Xu Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100193, ChinaCorrespondence[email protected]

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Abstract

Two new cassane-type diterpenes, neocaesalpin MR (1) and minaxin C (2), were isolated from Caesalpinia minax HANCE. The structures of these compounds were elucidated by means of spectroscopic analysis. Among these isolated compounds, neocaesalpin MR showed mild activities toward HeLa and colon cancer (HCT-8) human cancer cell lines.

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Acknowledgments

The work was supported by the technological large platform for comprehensive research and development of new drugs in the 11th Five-Year ‘Significant New Drugs Created’ Science and Technology Major Projects (No. 2009ZX09301-003), National Natural Science Foundation of China (No. 30973626), Innovation Capacity Building in Guangxi Science and Technology Agency (No. 10100027-3), National Science and Technology Support Program (No. 2012BA127B06), Guangxi Science and Technology Achievements Transformation Project (No. 1298009-22), and Nanning Science Research and Technology Development Program (No. 201102088C).

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Two new diterpenes, neocaesalpin MR and minaxin C, from Caesalpinia minax

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Two new diterpenes, neocaesalpin MR and minaxin C, from Caesalpinia minax

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