Two new sesquiterpenoids from the rhizomes of Nardostachys jatamansi

Abstract

Phytochemical investigation of CHCl₃:MeOH (1:1) extract from the rhizomes of Nardostachys jatamansi led to the isolation of two new sesquiterpenoids (5 and 6), along with six known compounds (1–4, 7, and 8). The structures of two new compounds were established using IR, MS, 1D, and 2D NMR techniques. In addition, all the isolates were tested for their cytotoxicities against the A549 (lung cancer), DU-145 (prostate cancer), MCF-7 (breast cancer), and SK-N-SH (neuroblastoma).

Keywords:

• Nardostachys jatamansi
• Valerianaceae
• sesquiterpenoids
• cytotoxicity

Acknowledgments

The authors are thankful to Dr J.S. Yadav, Director, Indian Institute of Chemical Technology for his constant encouragement and support.