Abstract
Chemical examination of the EtOAc extract from the stems of Hicriopteris glauca (Thunb) Ching. led to the isolation of two new compounds: lunularic acid 4′-glucoside (1) and 2,9-dihydroxy-4,7-megastigmadiene-3-O-β-glucoside (2). Their structures were elucidated on the basis of spectral analysis and by comparing their spectral data with those in literature. Two compounds, along with the petroleum ether, chloroform, EtOAc, and n-BuOH extracts, were tested for cytotoxic activities. Only the n-BuOH extract showed antitumor activity against human melanoma A375 cells with IC50 values of 0.80 μg/ml.
Acknowledgements
The work was financially supported by the Key Project of Chinese Ministry of Education (211060), Shanghai Education Committee (11ZZ112), Shanghai Leading Academic Discipline Project (J50302) and Shanghai Committee of Science and Technology, China (11ZR1434500).