Diterpenoid alkaloids from Aconitum kirinense

Abstract

A new C₁₈-diterpenoid alkaloid, kirinenine A (1), was isolated from the root of Aconitum kirinense, along with eight known diterpenoid alkaloids. The structures of all compounds were characterized on the basis of extensive NMR and MS analyses and by comparison with literature values, and the new one was further confirmed by X-ray crystallographic diffraction. All the compounds were isolated from the title plant for the first time.

Keywords:

• Aconitum kirinense
• Ranunculacea
• diterpenoid alkaloids
• kirinenine A

Acknowledgments

We thank Dr Shao-Min Wang, New Drug Research and Development Center of Zhengzhou University, for recording HR-ESI-MS spectra; Mrs Yu Zhu, Chemistry Department of Zhengzhou University for X-ray crystal; Prof. Feng-Wu Liu, New Drug Research and Development Center of Zhengzhou University, for the NMR spectra analysis.