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Abstract
Six new carboxylic acids (1–6), together with 11 known ones (7–17), were isolated from the aerial parts of Lysimachia clethroides. Their structures were elucidated on the basis of spectroscopic analysis and chemical evidence. Five new carboxylic acids (1 and 3–6) were evaluated for their in vitro inhibitory activity against aldose reductase.
Acknowledgements
This research work was supported by the National Science and Technology Project of China (No. 2011ZX09307-002-01). We thank the Department of Medicinal Analysis, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, for the measurements of IR, NMR, and HR-ESIMS spectra. We are also grateful to Ms Quan Liu and Zhu-Fang Shen (Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College) for the in vitro aldose reductase assay.