A new compound from liquid fermentation broth of Armillaria mellea and the determination of its absolute configuration

Yun-Chao Wang Institute of Genetics and Cytology, Northeast Normal University, Renmin Street 5268, Changchun, 130024, China; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Renmin Street 5268, Changchun, 130024, China; Research Center of Agriculture and Medicine Gene Engineering of Ministry of Education, Northeast Normal University, Renmin Street 5268, Changchun, 130024, China

Yu-Wei Zhang Institute of Genetics and Cytology, Northeast Normal University, Renmin Street 5268, Changchun, 130024, China; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Renmin Street 5268, Changchun, 130024, China

Li-Hua Zheng National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Renmin Street 5268, Changchun, 130024, China

Yong-Li Bao National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Renmin Street 5268, Changchun, 130024, China; Research Center of Agriculture and Medicine Gene Engineering of Ministry of Education, Northeast Normal University, Renmin Street 5268, Changchun, 130024, China

Yin Wu Institute of Genetics and Cytology, Northeast Normal University, Renmin Street 5268, Changchun, 130024, China; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Renmin Street 5268, Changchun, 130024, ChinaCorrespondence[email protected]

Chun-Lei Yu Institute of Genetics and Cytology, Northeast Normal University, Renmin Street 5268, Changchun, 130024, China; Research Center of Agriculture and Medicine Gene Engineering of Ministry of Education, Northeast Normal University, Renmin Street 5268, Changchun, 130024, China

Lu-Guo Sun National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Renmin Street 5268, Changchun, 130024, China; Research Center of Agriculture and Medicine Gene Engineering of Ministry of Education, Northeast Normal University, Renmin Street 5268, Changchun, 130024, China

Yu Zhang National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Renmin Street 5268, Changchun, 130024, China

Yan-Xin Huang National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Renmin Street 5268, Changchun, 130024, China

Ying Sun National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Renmin Street 5268, Changchun, 130024, China

Yu-Xin Li National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Renmin Street 5268, Changchun, 130024, China; Research Center of Agriculture and Medicine Gene Engineering of Ministry of Education, Northeast Normal University, Renmin Street 5268, Changchun, 130024, ChinaCorrespondence[email protected]

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Abstract

A new 2,5-diketopiperazine, (R)-2-(2-(furan-2-yl)-oxoethyl)-octahydropyrrolo[1,2-a]pyrazine-1,4-dione, and seven known compounds were isolated from the ethyl acetate extract of liquid fermentation broth of Armillaria mellea. The structures of the isolated compounds were established from NMR and HR-MS data. The absolute configuration of the new compound was established by comparing the experimental electronic circular dichroism (ECD) spectrum with the calculated ECD data.

Keywords:

Acknowledgments

This work was financially supported by National Natural Science Foundation of China (Grant Nos 30873409, 30670220, 31070318), National Key Technologies R&D Program of China (Grant No. 2007BA138B06), the Cultivation Fund of the Scientific and Technical Innovation Project of Northeast Normal University (Grant No. NENU-STB07008), the Research Foundation of Jilin Provincial Science & Technology Development (Grant No. 20102203), and the Fundamental Research Funds for the Central Universities. The theoretical calculation using Gaussian 09 was carried out at School of Chemistry, Northeast Normal University, Changchun, Jilin, China.

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A new compound from liquid fermentation broth of Armillaria mellea and the determination of its absolute configuration

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A new compound from liquid fermentation broth of Armillaria mellea and the determination of its absolute configuration

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