Two new triterpenoids from the fungus Perenniporia maackiae

Abstract

Two new triterpenoids, 3β-(2-methoxy-oxalyloxy)-24-methylene-lanost-8-en-21-oic acid (1) and 3β-(2-methoxy-oxalyloxy)-15α-hydroxy-24-methylene-lanost-8-en-21-oic acid (2), were isolated from cultures of the fungus Perenniporia maackiae, together with two previously known triterpenoids (3 and 4). Their structures were determined by spectroscopic methods, including 1D and 2D NMR, and MS analyses. All compounds were evaluated for their cytotoxic activities on five tumor cell lines.

Keywords:

• Perenniporia maackiae
• triterpenoids
• 3β-(2-methoxy-oxalyloxy)-24-methylene-5α-lanost-8-en-21-oic acid
• 3β-(2-methoxy-oxalyloxy)-15α-hydroxy-24-methylene-5α-lanost-8-en-21-oic acid
• cytotoxic activities

Acknowledgements

This work was financially supported by National Basic Research Program of China (973 Program, 2009CB522300) and the National Natural Science Foundation of China (U1132607).