Three new norlignans from Glechoma longituba

Abstract

Three new norlignans, glechomols A–C (1–3, respectively), together with a known compound, 4-ethylcatechol (4), were isolated from the ethyl acetate extract of Glechoma longituba (NaKai) Kupr. Their structures were elucidated by the detailed analysis of 1D and 2D NMR and HR-MS data. Glechomols A–C were the first norlignans reported from genus Glechoma, and compound 4 was also isolated from genus Glechoma for the first time. Intracellular antioxidant assays showed that compounds 1–4 displayed significant protective effects on H₂O₂-induced cardiac cell injury.

Keywords:

• Glechoma longituba
• norlignans
• glechomols A–C

Acknowledgments

This work was financially supported by National S&T Major Project (2009ZX09313-036).