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Abstract
In this paper, the microbial transformation of desacetylcinobufagin (1) by Fusarium avenaceum AS 3.4594 was investigated, and four metabolites were isolated and characterized as 3-keton-desacetylcinobufagin (2), 3-epi-desacetylcinobufagin (3), bufadienolide A (4), and 15β,16α-dihydroxyl-17βH-bufalin (5), respectively. Among them, 4 and 5 are new compounds. The cytotoxicities of transformed products (2–5) against Hela cells were also investigated.
Acknowledgements
We thank National Natural Science Foundation of China (81274047 and 81202589), Education Department of Liaoning Province (LS2010059) and Program for Liaoning Excellent Talents in University (LJQ2011095) for their financial support.
Notes
1. These authors contributed equally to this work.