Three new phenyl-ethanediols from the fruiting bodies of the mushroom Fomes fomentarius

Abstract

Three new phenyl-ethanediols, (1R)-(3-ethenylphenyl)-1,2-ethanediol (1), (1R)-(3-formylphenyl)-1,2-ethanediol (2), and (1R)-(3-acetophenyl)-1,2-ethanediol (3), were isolated from the fruiting bodies of the mushroom Fomes fomentarius, together with two related known compounds, (3-ethylphenyl)-1,2-ethanediol (4) and (4-acetophenyl)-1,2-ethanediol (5). Their structures were elucidated by spectroscopic methods including extensive 2D NMR techniques. Compounds 1–3 showed weak antimicrobial activity.

Keywords:

• Fomes fomentarius
• ethanediol
• antimicrobial activity

Acknowledgements

This work was financially supported by National Basic Research Program of China (973 Program, 2009CB522300) and the National Natural Science Foundation of China (30830113, U1132607).