Three new lanostanoid triterpenes from the fruiting bodies of Ganoderma tropicum

Abstract

Three new lanostanoid triterpenes, 3β,7β,15β-trihydroxy-11,23-dioxo-lanost-8,16-dien-26-oic acid (1), 3β,7β,15β-trihydroxy-11,23-dioxo-lanost-8,16-dien-26-oic acid methyl ester (2), and 3β,15β-dihydroxy-7,11,23-trioxo-lanost-8,16-dien-26-oic acid methyl ester (3) were isolated from the EtOAc extract of the fruiting bodies of Ganoderma tropicum. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopy as well as MS. The bioassay of inhibitory activity against acetylcholinesterase (AChE) of these isolates was evaluated and compound 2 exhibited definite inhibitory activity against AChE.

Keywords:

• Ganoderma tropicum
• Ganodermataceae
• lanostanoid triterpene
• AChE inhibitory activity

Acknowledgments

The authors thank the Natural Science Foundation of Hainan (211020), the National Nonprofit Institute Research Grant of CATAS (ITBB110301 and 1630052012014), and Special Fund for Agro-scientific Research in the Public Interest (201303117) for financial support. The authors are grateful to the members of the analytical group of the Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences for the spectral measurements.

Notes

1. These authors contributed equally to this work.

Additional information

Notes on contributors

Li-Li Hu

1

Qing-Yun Ma

1