Two new tri-nor-eudesmanolides from Inula racemosa

Abstract

Two new tri-nor-eudesmane-type sesquiterpenoids were isolated from the roots of Inula racemosa, and their structures were elucidated as 8-oxo-tri-nor-eudesm-6-en-5α-ol (1) and tri-nor-eudesm-5-en-7β,8β-diol (2). The cytotoxic activity of compound 1 against five human cancer cell lines had been tested, but exhibited no cytotoxic activity.

Keywords:

• Inula racemosa
• sesquiterpenoids
• tri-nor-eudesmanolides

Acknowledgments

This research program was financially supported by National Science and Technology Project of China (Nos. 2011ZX09307-002-01, 2012ZX09103201-043) and Key Laboratory of Polymorphic Drugs of Beijing.