Synthesis, anticancer, and antibacterial activities of piplartine derivatives on cell cycle regulation and growth inhibition

Abstract

A series of piplartine derivatives were synthesized via Baylis–Hillman reaction and evaluated for anticancer and antibacterial activities. The cytotoxicity of these compounds was examined in two different human tumor cell lines, IMR-32 and HeLa. The antibacterial activity was examined in Staphylococcus aureus and Pseudomonas aeruginosa. The results showed that compounds 2b, 2e, and 2j were found to be the most active compounds, which displayed line no cytotoxicity, but G2–M cell cycle arrest in tumor cells, and showed cytostatic effects in bacteria.

Keywords:

• Piper chaba
• piplartine
• piplartine derivatives
• anticancer activity
• antibacterial activity

Acknowledgements

The authors gratefully acknowledge keen interest of Dr J. S. Yadav, Director, IICT, Hyderabad, India. RSCK and BP thank CSIR, New Delhi for financial support.