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Original Articles

Structural features of a polysaccharide from Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao

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Pages 687-692 | Received 28 Jun 2012, Accepted 10 Feb 2013, Published online: 10 May 2013
 

Abstract

A polysaccharide Astragalus polysaccharide (APS) was obtained from the boiling water extract of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao. The results of gas chromatography (GC) indicated that APS consisted of l-rhamnose (l-Rha), d-xylose (d-Xyl), d-glucose (d-Glc), and d-galactose (d-Gal) in the molar ratio of 1:4:5:1.5. Its molecular weight was determined to be 3.01 × 105 by high-performance gel filtration chromatography. The results of 1H NMR and 13C NMR spectral analysis indicated that APS had a linear backbone mainly consisting of 1,3-linked β-d-Gal residues with insertion of β-Glc, 1,6-linked α-Gal, 1,5-linked β-Xyl, 1,4-linked β-Gal, β-d-Gal, 1,2-linked α-Rha, 1,2,4-linked α-Rha residues. HSQC spectrum indicated that C-2 and C-6 may link with H.

Acknowledgements

This work was financially supported by the Key National Natural Science Foundation of China (81130069); selected program of Personnel Department for Oversea Scholar (2009–2011); the Chinese National S&T Special Project on Major New Drug Innovation (2011ZX09307-002-01); the key technologies of the quality standards and the safety of health food, ‘863 Program’ (2010AA023006).

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