Two new neuroprotective phenolic compounds from Gastrodia elata

Abstract

Two new phenolic compounds 4-(4′-hydroxybenzyl) phenyl glucoside (gastrodin B, 1) and 1′-hydroxymethyl-phenyl 4-hydroxy-3-(4″-hydroxybenzyl) benzyl ether (gastrol B, 2) were isolated from the rhizomes of Gastrodia elata. Their structures were elucidated on the basis of spectroscopic data and chemical reaction. All compounds exhibited potent neuroprotective activity against H₂O₂-induced PC12 cell damage.

Keywords:

• Gastrodia elata
• phenolic compounds
• gastrodin B
• gastrol B
• neuroprotective activity