Two new cholinesterase inhibitors asiatoates A and B from Buddleja asiatica

Farman Ali Department of Chemistry, Gomal University, Dera Ismail Khan, 27100, KPK, Pakistan

Hidayat Ullah Khan Department of Biotechnology, University of Science and Technology, Bannu, 28100, KPK, Pakistan

Masood Afzal Department of Chemistry, Gomal University, Dera Ismail Khan, 27100, KPK, Pakistan

Abdul Samad Department of Chemistry, Gomal University, Dera Ismail Khan, 27100, KPK, Pakistan

Shafi Ullah Khan Department of Chemistry, Gomal University, Dera Ismail Khan, 27100, KPK, Pakistan

Irshad Ali Department of Chemistry, Gomal University, Dera Ismail Khan, 27100, KPK, PakistanCorrespondence[email protected] [email protected]

Abstract

Two new benzoates, asiatoate A (1) and asiatoate B (2), have been isolated from the ethyl acetate soluble fraction of Buddleja asiatica whole plant. Their structures were elucidated with the help of spectroscopic data. Both showed significant inhibitory effect on acetylcholinesterase (AChE) and butylcholinesterase (BChE) in a dose-dependent manner. The IC₅₀ values of compounds 1–2 were 5.54 and 8.34 μM against AChE while 30.94 and 35.94 μM against BChE, respectively.

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Acknowledgment

The author is thankful to Higher Education Commission of Pakistan for providing financial support under HEC 5000 PhD Indigenous Fellowship Program.

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Two new cholinesterase inhibitors asiatoates A and B from Buddleja asiatica

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Two new cholinesterase inhibitors asiatoates A and B from Buddleja asiatica

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