Two new compounds from Khaya senegalensis

Abstract

Two new compounds, khayseneganin I (1) and 2α,3α,16β-trihydroxy-20-acetoxy-20(R)-pregnane (2), along with six known compounds, 2α,3α,20-trihydroxy-16β-acetoxy-20(R)-pregnane (3), 2α,3β-dihydroxypregnan-16-one-2β,19-hemiketal (4), (+)-catechin (5), ivorenolide A (6), luteolin-7-O-α-l-rhamnoside (7), and ( − )-5′-methoxy-isolariciresinol-2a-O-β-d-xylopyranoside (8), were isolated from the leaves and twigs of Khaya senegalensis. The structures of new compounds were elucidated by 2D NMR spectroscopy and MS. Selected compounds (2–8) were evaluated for their antimicrobial activities and compounds 5 and 7 showed weak antimicrobial activities against MRSA 92^# and MRSA 98^#.

Keywords:

• Khaya senegalensis
• limonoid
• steroid
• antimicrobial activitites

Acknowledgements

The work was financially supported by the National Natural Science Foundation of China (No. 30830114), the Ministry of Science and Technology (2009CB522300 and 2009CB 940900), and the Young Academic and Technical Leader Raising Foundation of Yunnan Province (2010CI047).