A concise synthesis of xestospongic acid methyl ester with pancreatic lipase inhibitory activity

Jing-Xu Gong State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China

He-Yao Wang State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China

Wen-Fei He State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; Wenzhou Medical College, Wenzhou, 325035, China

Zhen-Zhong Wang Jiangsu Kanion Pharmaceutical Co. Ltd, Lianyungang, 222001, China

Wei Xiao Jiangsu Kanion Pharmaceutical Co. Ltd, Lianyungang, 222001, ChinaCorrespondence[email protected]

Yue-Wei Guo State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, ChinaCorrespondence[email protected]

Abstract

Xestospongic acid methyl ester, a naturally brominated fatty acid with potent pancreatic lipase inhibitory activity in vitro, was synthesized from 5-hexynol in 30% total yield.

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Acknowledgments

The research work was financially supported by the Natural Science Foundation of China (Nos 81072572, 81273430, and 21021063), National Marine ‘863’ Project (Nos 2011AA09070102 and 2013AA092902), the SKLDR/SIMM Projects (Nos SIMM1203ZZ-03, SIMM1105KF-04, and SIMM1203KF-12), W.-F.H. thanks China Postdoctoral Science Foundation Grant (No. 2012M520956).

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A concise synthesis of xestospongic acid methyl ester with pancreatic lipase inhibitory activity

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A concise synthesis of xestospongic acid methyl ester with pancreatic lipase inhibitory activity

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