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Abstract
Two new naphthaline glucosides, 2-hydroxy-3-methoxy-8-methyl-1-O-β-d-glucopyranosylnaphthaline (1) and 1-hydroxy-3-methoxy-8-methyl-2-O-β-d-glucopyranosylnaphthaline (2), together with one new isocoumarin glucoside, 3-(3,3-dichloro-2-hydroxylpropyl)-6-methoxy-8-O-β-d-glucopyranosyl-1H-isochromen-1-one (3), were isolated from a cold-adapted fungal strain Mucor sp. (No. XJ07027-5). Their structures were characterized by detailed analyses of IR, MS, 1D- and 2D-NMR spectra. Among them, 2 showed moderate cytotoxic activity against five tumor cells (A-549, HL-60, MCF-7, SMMC-7721, and SW480).
Acknowledgements
This research work was financially supported by grants from the Ministry of Science and Technology of China (2009CB522300 and 2012ZX09301002-003), the program for New Century Excellent Talents in University (NCET-10-0120) from the Ministry of Education of China, and the Fundamental Research Funds for the Central Universities (21611203).
Notes
1. These two authors contributed equally to the work reported in this article.