Polyketides from the plant endophytic fungus Cladosporium sp. IFB3lp-2

Abstract

Chemical study of the ethyl acetate extract of the plant endophytic fungus Cladosporium sp. (strain no. IFB3lp-2) yielded three new polyketides (1–3), together with nine known compounds. All of the structures were elucidated on the basis of spectroscopic methods. The isolated compounds were screened for their cytotoxic, antiviral, and acetyl cholinesterase inhibitory activities. Regretfully, no compounds showed any significant activity in these assays.

Keywords::

• Cladosporium sp
• polyketide
• macrolide
• structure elucidation

Acknowledgments

This work was cofinanced by the National Natural Science Foundation (81121062, 81172948, 21132004, 30901846, 90813036, and 21072092), New Century Excellent Talents in University (NCET-10-0477), Jiangsu Provincial Government (BK2009010), Ministry of Science and Technology of China (2011AA09070204, 2013AA092903, and 2013AA092901).