A new protopanaxadiol-type ginsenoside from the roots of Panax notoginseng

Abstract

A new protopanaxadiol-type ginsenoside, 6-O-β-d-glucopyranosyl-20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol-3-one (1), along with three known compounds, was isolated from the roots of Panax notoginseng. Their structures were determined based on some pieces of spectroscopic and chemical evidence. Compound 1 exhibited cytotoxic activity against five human cancer cell lines, with IC₅₀ values ranging from 5.4 to 8.6 μg/ml.

Keywords::

• Panax notoginseng
• protopanaxadiol
• cytotoxicity

Acknowledgements

The authors thank the National Science Foundation of China (NSFC, Grant No. 21132009). The authors are grateful to Prof. X.J. Jing for NMR measurements, Prof. J.B. Li for ESI-MS measurements, and Prof. X.G. Chen for bioassay.