Two new terpenoid benzoates with antitumor activity from the roots of Ferula dissecta

Abstract

Two new sesquiterpene benzoates, syreiteate A (1) and syreiteate B (2), were isolated from the roots of Ferula dissecta (Ledeb.) Ledeb. Their structures were elucidated by extensive spectroscopic methods including 1D (¹H and ¹³C) NMR, 2D (HSQC, HMBC, DQF-COSY, and NOESY) NMR, and ESI-TOF-MS. Their configurations were determined on the basis of the analysis of the coupling constants, NOESY correlations, and circular dichroism spectrum. Compounds 1 and 2 showed potent growth inhibitory activity against cervical cancer HeLa cell line with the IC₅₀ values of 13.2 and 19.3 μM, respectively.

Keywords::

• Ferula dissecta
• syreiteate A
• syreiteate B
• NMR
• CD
• antitumor activity

Acknowledgments

This research was partially sponsored by National Key Technology R&D Program (2012BAI30B02) and National Natural Science Foundation (U1170302). The authors acknowledge Waters Co. Ltd for Cooperation Laboratory and Dr Yong Tan for identification of plant material.