Phenolic glycosides and other constituents from the bark of Magnolia officinalis

Abstract

A new phenolic glycoside, syringic acid 4-O-β-d-glucopyranosyl-(1 → 5)-α-l-rhamnopyranoside (1), together with 12 known compounds consisting of eight phenolic glycosides (2–9), two phenolic acids (10 and 11), and two norsesquiterpenoids (12 and 13), was isolated from the methanol extract of the bark of Magnolia officinalis. Their structures were elucidated on the basis of spectroscopic analysis and chemical methods. Compounds 1–11 were evaluated for their inhibitory activities against fructose-1,6-bisphosphatase, aldose reductase, lipase, dipeptidyl peptidase-IV, α-glucosidase, and three cancer cell lines. However, all the compounds showed weak or no activities in these tests.

Keywords::

• Magnoliaceae
• Magnolia officinalis
• phenolic glycoside
• syringic acid 4-O-β-d-glucopyranosyl-(1 → 5)-α-l-rhamnopyranoside

Acknowledgements

This project was financially supported by the National Natural Science Foundation of China (No. 81073042) and the Research Fund of China Academy of Chinese Medical Sciences (No. ZZ20090108).