Three new compounds from the cultures of basidiomycete Boreostereum vibrans

Abstract

Three new compounds, vibranether (1), myrrhlalkyldiol (2), vibralactone H (3), together with three known compounds, 2-methyl-6-p-tolylheptane-2,3-diol (4), 2-hydroxy-2-methyl-6-p-tolylheptan-3-one (5), and vibralactone (6), were isolated from the cultures of the basidiomycete Boreostereum vibrans. Their structures were determined on the basis of spectroscopic evidences (1D and 2D NMR, HRMS, UV, and IR data), chemical methods, and the literature data. The new compounds displayed no significant cytotoxicities against five human cancer cell lines (IC₅₀>40 μM).

Abstract

Keywords::

• Boreostereum vibrans
• basidiomycete
• vibralactone derivatives

Acknowledgments

This project was financially supported by the National Basic Research Program of China (973 Program, 2009CB522300), the National Natural Science Foundation of China (U1132607, 81102346), and Hunan Province Innovation Foundation for Postgraduate (CX2012B160).