Two new phthalides with BuChE inhibitory activity from Ligusticum chuanxiong

Abstract

Two new phthalides, chuanxiongdiolides A (1) and B (2), were isolated from the roots of Ligusticum chuanxiong Hort. Their structures were established by UV, IR, 1D (¹H, ¹³C) and 2D (HSQC, ¹H–¹H COSY, HMBC, NOESY) NMR, and HR-ESI-MS methods, and their absolute configurations were assigned via circular dichroism exciton chirality. The two compounds showed different degrees of inhibitory effects against butyrylcholine esterase.

Keywords::

• Ligusticum chuanxiong
• chuanxiongdiolide A
• chuanxiongdiolide B
• NMR
• CD
• anti-BuChE activity

Acknowledgments

This work was financially supported by Key Projects of the National Science and Technology Pillar Program (No. 2012BAI30B02).