Three new ursane-type triterpenoids from the aerial parts of Isodon excisoides

Abstract

Three new ursane-type triterpenoids, 2α,3β-dihydroxy-11α,12α-epoxy-urs-28,13β-olide (1), 2α,3β,24-trihydroxy-11α,12α-epoxy-urs-28,13β-olide (2), and 2α,3α,24-trihydroxy-11,20(30)-dien-urs-28,13β-olide (6), together with six known ursane-type triterpenoids (3–5, 7–9), were isolated from the EtOAc extract of the aerial parts of Isodon excisoides. Their structures were elucidated on the basis of 1D NMR and 2D NMR analyses as well as HRMS experiments.

Keywords::

• Isodon excisoides
• ursane
• triterpenoid

Acknowledgments

This work was financially supported by the opening fund of Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Huazhong University of Science and Technology. We are grateful to pharmacist C.R. Wang (Enshi Food and Drug Administration, Hubei Province, China) for medicinal material collection.