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Articles

New sesquiterpenoid derivatives from Solanum lyratum and their cytotoxicities

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Pages 129-134 | Received 21 Apr 2013, Accepted 25 Aug 2013, Published online: 29 Oct 2013
 

Abstract

Three new sesquiterpenoid isopropylidene derivatives, named solajiangxins H and I (1 and 2) and 7-hydroxylsolajiangxin I (3), were isolated from the whole plant of Solanum lyratum. Their structures were elucidated on the basis of integrated spectroscopic techniques, mainly HR-FAB-MS, 1D NMR, and 2D NMR (1H–1H COSY, HMQC, HMBC, and NOESY). In vitro, compounds 13 were found to show significant cytotoxicity against three cancer cells (P-388, HONE-1, and HT-29), and gave IC50 values in the range of 3.2–7.7 μM.

Acknowledgments

This study was financially supported by the Natural Science Foundation of Shandong Province (No. ZR2009CZ004). The authors are grateful to Ms Wen-Yan Wang and Li Shen (School of Pharmaceutical Science, Yantai University) for the measurements of FAB-MS, HR-FAB-MS, UV, IR, and NMR spectra, respectively. The authors also gratefully acknowledge Mr Hong-Bo Wang (School of Pharmaceutical Science, Yantai University) for the bioactivity screenings.

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