A new trichothecene from Myrothecium roridum QDFE005, a symbiotic fungus isolated from Mactra chinensis

Abstract

A new trichothecene, 12′-episatratoxin H (1), together with three known analogs: roridin A (2), 16-hydroxyroridin E (3), and roridin E (4), was isolated from the culture broth of the symbiotic fungus Myrothecium roridum QDFE005, which was isolated from Mactra chinensis. Their structures were elucidated on the basis of spectroscopic methods, including 1D and 2D NMR (COSY, HMQC, and HMBC) techniques. Compound 1 exhibited significant cytotoxicity against the human tumor cell lines KB and HepG2 with IC₅₀ values of 1.42 and 2.27 μM, respectively.

Keywords::

• Myrothecium roridum
• Mactra chinensis
• 12′-episatratoxin H
• cytotoxicity

Acknowledgments

The authors thank the financial support from the Natural Science Foundation of Shandong Province (No. ZR2009BQ007), Science and Technology Development Plan Foundation for Young Scientists of Qingdao City (No. 13-1-4-199-jch) and Science and Technology Innovation Foundation of Yangzhou University (2011CXJ081).