Indole Alkaloids from Leaves and Twigs of Rauvolfia verticillata

Abstract

Seven new indole alkaloids, rauverines A–G (1—7), and 19 known indole alkaloids were isolated from the leaves and twigs of Rauvolfia verticillata. All compounds showed no cytotoxicity against five human cancer cell lines, human myeloid leukemia (HL-60), hepatocellular carcinoma (SMMC-7721), lung cancer (A-549), breast cancer (MCF-7), and colon cancer (SW480) cells.

Keywords::

• Rauvolfia verticillata
• monoterpenoid indole alkaloid
• rauverines A–G
• structure elucidation

Acknowledgments

This work was financially supported by the National Natural Science Foundation of China (Nos 21172225 and 31370377), the Young Academic and Technical Leader Raising Foundation of Yunnan Province (No. 2010CI049), and the Chinese Academy of Sciences (XiBuZhiGuang Project).