Two new isoflavone glycosides from the vine stem of Millettia dielsiana

Abstract

Two new isoflavone glycosides, millesianins F (1) and G (2), along with 11 known ones (3–13) have been isolated from the n-butanol extract of the vine stems of Millettia dielsiana Harms. The structures of 1 and 2 were established as cladrastin 7-O-β-d-apiofuranosyl-(1 → 6)-β-d-glucopyranoside (1) and fujikinetin 7-O-β-d-apiofuranosyl-(1 → 6)-β-d-glucopyranoside (2) by means of spectroscopic analysis and chemical methods. Some isolates (compounds 1, 3, 4, 5, 6, and 11) were tested for their effects on the proliferation of hematopoietic progenitor cell, and the preliminary results showed that all of investigated compounds had moderate activities but not in dose-dependent manners.

Keywords::

• Millettia dielsiana
• Leguminosae
• millesianins F and G
• isoflavone glycosides

Acknowledgements

The authors are grateful to the Department of Instrumental Analysis, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, for the measurement of the IR and NMR spectra. This research program was financially supported by the National Science and Technology Project of China (2012ZX09301002001003).