Synthesis of three OSW-1 analogs with maltose side chains bearing different protection groups

Abstract

In order to simplify the synthesis of OSW-1's disaccharide side chain and explore the structure–activity relationship of OSW-1, three 16α-O-maltose OSW-1 analogs carrying three maltose side chains bearing different protections were designed and synthesized.

Keywords::

• OSW-1
• antitumor
• synthesis
• maltose

Acknowledgments

Financial support of this research by the National Natural Science Foundation of China (NNSFC 30772632) and the National Program of New Drug Innovation and Production (2009ZX09301-003-9-1) is gratefully acknowledged by the authors.