A new dihydroagarofuranoid sesquiterpene from the roots of Tripterygium hypoglaucum

Abstract

A new sesquiterpene ester (1) has been isolated from the root bark of Tripterygium hypoglaucum. The structure was determined as 1α-acetoxy-6β,9β-dibenzoyloxy-4β-hydroxy-dihydroagarofuran by the extensive analysis of NMR data, and the absolute configurations were established as 1R, 4R, 6S, and 9R by application of the CD excitation chirality method. Compound 1 exhibited weak cytotoxicity against HeLa cells, with an IC₅₀ value of 30.2 μM.

Keywords::

• dihydroagarofuranoid sesquiterpene
• Tripterygium hypoglaucum
• Celastraceae
• 1α-acetoxy-6β,9β-dibenzoyloxy-4β-hydroxy-dihydroagarofuran

Acknowledgments

We gratefully acknowledge financial support from Chinese National S&T Special Project on Major New Drug Innovation (2011ZX09307-002-01) and Program for Innovative Research Team in IMPLAD.