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Abstract
This work presents the metabolites of isocorynoxeine (ICOR), which is one of four bioactive tetracyclic oxindole alkaloids isolated from Uncaria hooks used commonly in the traditional Chinese medicines and Kampo medicines. After oral administration of 40 mg kg− 1 ICOR to rats, bile was drained and analyzed by LC-MS. Two phase I metabolites, namely 11-hydroxyisocorynoxeine (M1) and 10-hydroxyisocorynoxeine (M2), and two phase II metabolites, namely 11-hydroxyisocorynoxeine 11-O-β-d-glucuronide (M3) and 10-hydroxyisocorynoxeine 10-O-β-d-glucuronide (M4), were isolated from rat excreta and bile, respectively, whose structures were elucidated on the basis of CD, NMR, and MS.
Additional information
Funding
This work was sponsored by the 44th Batch of Scientific Research Foundation for the Returned Overseas Chinese Scholars (to WW), State Education Ministry, China, also financially supported by Yunnan Provincial Research Program of Application Foundation [general grant number 2012FB154], [general grant number 2013FZ061], [general grant number 2013FB121]; Yunnan Provincial Education Bureau Research Foundation [grant number 2014Y158], [2013Y296].