Two new glycosides from the fruits of Forsythia suspense

Abstract

Two new glycosides suspensaside C (1) and 2,3,5,6-tetrahydro-jacaranone-4-O-β-d-glucopyranoside (2), together with four known compounds suspensaside A (3), rengynic acid-1′-O-β-d-glucopyranoside (4), forsythoside A (5), and rengynic acid (6), were isolated from the fruits of Forsythia suspense (Thunb.) Vahl. The structures of 1 and 2 were elucidated on the basis of chemical and spectral analysis, including 1D, 2D NMR analyses and HR-ESI-MS. All isolates were tested for their cytotoxicities against five human cancer cell lines (A549, Colo-205, Hep-3B, HL60, and KB). Compound 3 exhibited cytotoxicity against HL-60, Hep-3B, and A549 cancer cell lines.

Keywords::

• Forsythia suspense
• glycosides
• cytotoxicitiy

Acknowledgments

The authors thank Mrs Ying Peng, Mrs Wen Li, and Mr Yi Sha of Shenyang Pharmaceutical University for the recording of HR-ESI-MS and NMR spectra.