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Abstract
Microbial transformation of the oleanolic acid (1) using Trichothecium roseum (pers.) Link (M 95.56) has resulted in the isolation of two new hydroxylated type metabolites, characterized as 15α-hydroxy-3-oxo-olean-12-en-28-oic acid (2) and 7β,15α-dihydroxy-3-oxo-olean-12-en-28-oic acid (3). The structure elucidation of these metabolites was based primarily on HR-EIMS, 1D NMR, and 2D NMR analyses.
Acknowledgments
This work was financially supported by grant from the Mega-project for Innovative Drugs (No. 2012ZX09301002-001-005) and the Fundamental Research Funds for the Central Universities (2012N06). The authors are grateful to the Department of Instrumental Analysis of our Institute for measurement of the IR, NMR, and MS data.